Risk factors for recurrent aphthous stomatitis: a systematic review / Factores de riesgo para la estomatitis aftosa recurrente: revisión sistemática

SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.

RESUMEN: Aún se desconoce la causa y cómo prevenir la estomatitis aftosa recurrente (más conocida como aftas). En esta revisión sistemática (registro PROSPERO #CRD42019122214) mostramos que la mayoría de los factores de riesgo para la enfermedad son polimorfismos genéticos de un solo nucleótido en genes relacionados con el funcionamiento del sistema inmune (TLR4, MMP9, E- selectin, IL-1 beta y TNF-alfa). Los polimorfismos genéticos de un solo nucleótido no constituyen un riesgo modificable.Ello indica que, al menos en parte, la susceptibilidad para las aftas es hereditaria y que esos factores no pueden ser modificados.

Prevalencia de lesiones bucales en tejido blando encontradas en la Clínica de Estomatología de la Facultad de Odontología de la Universidad de los Andes: periodo 2015-2018 / Prevalence of oral lesions in soft tissue found in the Clinic of Stomatology of the Faculty of Dentistry of the University of los Andes: 2015-2018 period

Introducción: La epidemiología sobre alteraciones en tejidos blandos bucales es limitada cuando se compara con caries, enfermedades periodontales y maloclusiones, por lo que su estudio representa un paso adelante en la odontología más allá de los dientes. Objetivo: Describir la prevalencia de las lesiones bucales en tejido blando encontradas en la Clínica de Estomatología de la Facultad de Odontología de la ULA, del 2015 al 2018, con la finalidad de proporcionar una fuente de datos actualizada, que oriente a una mejor prevención y oportuno diagnóstico. Material y métodos: Se realizó una investigación descriptiva, documental, retrospectiva y multivariable. Resultados: De 1,000 fichas clínicas estudiadas, las patologías más frecuentes fueron: lengua saburral (50.6%), queilitis (33.4%), traumatismo de la mucosa de los carrillos (27.6%), várices linguales (18.3%), anquiloglosia (13.7%) y agrandamiento de rugas palatinas (11.7%). La zona con mayor alteración fue la lengua (92.1%), mientras que el paladar fue la menos afectada (29%). De los hábitos predisponentes a la formación de lesiones, el mordisqueo de mucosa fue el más común (16.5%). En cuanto a los factores locales asociados, una higiene oral regular/ deficiente resultó el principal (53.8%). Conclusión: La educación del paciente sigue siendo considerada la clave para disminuir la aparición de patologías y su evolución a entidades más graves (AU)

Introduction: Epidemiological studies on soft tissue alterations in the mouth are limited when compared with caries, periodontal diseases and malocclusions, so their study represents a step forward in dentistry beyond the teeth. Objective: To describe the prevalence of soft tissue oral lesions found in the Stomatology Clinic of the ULA School of Dentistry, from 2015 to 2018, in order to provide an up-to-date data source, to guide better prevention and timely diagnosis. Material and methods: A descriptive and documentary, retrospective and multivariable research was carried out. The statistical package IBM SPSS Statistics v 23 was applied for the analysis. Results: 1,000 clinical records studied, the most frequent pathologies were: saburral tongue (50.6%), cheilitis (33.4%), traumatism of the cheek mucosa (27.6%), lingual varices (18.3%), ankyloglossia (13.7%) and enlargement of palatal rugas (11.7%). The tongue was the most affected (92.1%), while the palate was the least affected (29%). Of the predisposing habits to the formation of lesions, mucosal nipping was the most common (16.5%). Regarding the associated local factors, a regular / deficient oral hygiene was the main one (53.8%). Conclusion: Patient education is still considered the key to diminish not only the appearance of pathologies but their evolution to more serious entities (AU)

Fiebre periódica con estomatitis aftosa, faringitis, y adenitis / Periodical fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA syndrome)

RESUMEN Se presenta un caso de fiebre periódica con estomatitis aftosa, faringitis, y adenitis síndrome de fiebre periódica con estomatitis aftosa, faringitis, y adenitis, entidad aparentemente infrecuente de la cual no se recoge reporte en el país. La etiología no es todavía bien comprendida, se observa con mayor frecuencia entre los 2 y 5 años, aunque se han descrito casos en adultos. Se caracteriza por fiebre periódica con estomatitis aftosa, faringitis, y adenitis de carácter periódica con una dramática respuesta al uso de esteroide en la mayoría de los casos. El caso que se presenta es un paciente de 5 años de edad, sexo masculino, con cuadros de fiebre periódica asociado a amigdalitis con exudado, adenitis y lesiones aftosas, con respuesta en la fase aguda a la prednisona y con respuesta al tratamiento de mantenimiento con cimetidina. En la actualidad lleva 11 meses en remisión (AU).

ABSTRACT We present a case of periodical fever with aphthous stomatitis, pharyngitis and adenitis (PFAPA syndrome), entity that is apparently infrequent and its report in the country was not found. Its etiology is not still clearly understood. It appears with higher frequency in the ages between 2 and 5 years, though it has been described in adult population. It is characterized by periodical fever with aphthous stomatitis, pharyngitis and adenitis of periodical character, with a dramatic answer to the use of steroids in most of the cases. The case that is presented is the one of a male patient aged 5 years with reiterative periodical fever associated to tonsillitis with exudate, adenitis and aphthous lesions, with answer, in the acute phase, to prednisone, and to cimetidine at the maintenance therapy. Nowadays, he is already 11 months in remission (AU).

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Abstract: BACKGROUND: Recurrent aphthous ulcerations are common benign ulcerated lesions on the mouth, whose etiology is poorly understood, with controversial treatment and difficult to control in clinical practice. OBJECTIVE: To evaluate the cases of recurrent aphthous ulcerations with a focus on treatment, diagnosis and etiology. METHODS: This is a retrospective study of the cases of the Oral Diagnosis service of the Rio Grande do Norte Federal University in Natal/RN. Data such as sex, age, race, location, smoking habits, types of treatment, relapsing episodes, laboratory test results and clinical characteristics were collected. The associations between the variables were analyzed using the Pearson Chi-square test (p <0.05). RESULTS: A total of 4895 patients were seen in the service over a period of 11 years. Of these, 161 (3.3%) had complaints of oral aphthous ulcerations, of which 76 (47.2%) were diagnosed as suffering from recurrent aphthous ulcerations and 68 (42.2%) with clinical information necessary for evaluation. The tongue was the most affected anatomical region, with 27 individuals (39.7%), followed by the buccal mucosa, with 22 cases (32.3%). STUDY LIMITATIONS: Retrospective study with data from medical records. CONCLUSION: Dental surgeons, dermatologists and otorhinolaryngologists are the main responsible for the first contact with patients with this disease and should be attentive to the clinical aspects and treat each patient in an individualized way, since the therapy is palliative, its diagnosis is by exclusion and its etiology is unknown.

Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study

Abstract: Background: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults. Objectives: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. Methods: Interview during clinical examination in the army. Results: In this group (2,427 interviewed adolescents) there was a RAS prevalence of 24.9%. Smoking, herpes labialis and socioeconomic status correlated with the outcome. Study Limitations: only male adolescents were interviewed. Conclusions: Our results showed high prevalence of RAS; association with higher economic level and herpes simplex was found. Protective effect of smoking was confirmed.

Prevalence of oral mucosal lesions in children / Prevalencia de lesiones de la mucosa oral en niños

Lesions of the oral mucosa are a broad range of different alterations located in the soft tissue of the oral cavity. The studies that describe the prevalence of oral mucosal lesions have been carried out mainly in an adult population. Therefore, in the literature available both in Chile and abroad, there are few reports about pathological lesions and alterations of the normality of the oral mucosa in pediatric population. A descriptive observational cross-sectional study was conducted, with non-probability sampling for convenience, with a sample of 219 patients and a level of confidence of 95 %. We estimated 30 % of children with oral mucosal lesions. Patient history and the presence of oral mucosal lesions were registered in the clinical records specific to this study. In 101 patients a prevalence of 37.62 % of oral mucosal lesions was observed. The most frequent lesion was the minor aphthous ulcer (6.9 %), followed by irritation fibroma (5 %), traumatic ulcer (5 %), traumatic erosion (4 %), impetigo (4 %), pigmented lesion (3 %), and others, at lower rates. The most prevalent location was the lips with a 38.5 %.

Las lesiones de la mucosa oral comprenden un amplio conjunto de alteraciones que se localizan en los tejidos blandos de la cavidad oral. Los estudios que describen la prevalencia de lesiones de mucosa oral, se han realizado principalmente en población adulta, por lo tanto en la literatura internacional y en Chile, existen escasos reportes acerca de lesiones patológicas y alteraciones de la normalidad de mucosa oral en población pediátrica. Se realizó un estudio observacional, descriptivo y transversal, de tipo no probabilístico por conveniencia, donde se calculó una muestra de 219 pacientes con un nivel de confianza de 95 %. Se estimó un porcentaje de 30 % de niños con lesiones de mucosa oral. Se registró la anamnesis del paciente y presencia de lesiones de mucosa oral en la ficha clínica específica para el estudio. Se observó en 101 pacientes una prevalencia de 37,62 % de lesiones de mucosa oral. La lesión más frecuente fue el afta menor, seguido de fibroma irritativo, úlcera traumática, erosión traumáticas, impétigo, lesiones pigmentadas y entre otras con menor frecuencia. La localización más prevalente fue los labios con 38,5 %.

Lesiones de la mucosa bucal en una población infantil de Montevideo, Uruguay / Oral mucosal lesions in a child population of Montevideo, Uruguay

Justificación: Existen escasos estudios que documenten la frecuencia de lesiones de la mucosa bucal en niños y adolescentes, y todos revelan resultados dispares.Materiales y método: Se realizó un estudio observacional, descriptivo, transversal, en niños de 3 a 12 años de edad que participan del Programa de Salud Bucal de la Facultad de Odontología de la Universidad Católica del Uruguay. Se tomaron en cuenta lesiones en la totalidad de la cavidad bucal, describiendo y registrando cada uno de los hallazgos. Se seleccionaron las 7 lesiones más frecuentes enla bibliografía consultada. Se realizó un análisis estadístico según edad, género y tipo de dentición.Resultados: Se estudiaron 191 sujetos; 103 presentaron alguna lesión. La lesión identificada con mayor frecuencia fue Morsicatio buccarum es decir, mordisqueo de mucosa yugal (trauma inflingido). La siguiente lesión más frecuente fue Lengua geográfica.Conclusiones: Las niñas tuvieron mayor probabilidad de presentar algún tipo de lesión que los niños. El rango de edades de 6-9 años tuvo mayor riesgo de presentar alguna lesión que el grupo de 9-12 años. Los sujetos con dentición mixta tuvieron más riesgo de presentarMorsicatio buccarum que el grupo de dentición permanente. Asimismo, los individuos de 6-9 años tuvieron mayores posibilidades de presentar Morsicatio buccarum que el grupo de 9-12 años. No se encontró un estudio epidemiológicamente comparable que describa las mismas lesiones que éste; esto lleva a concluir que es necesario realizar otros estudios con la misma metodología y ampliando los criterios diagnósticos.

Justification: There are few studies that document the frequency of oral mucosal lesions in children and adolescents, and all of them reveal different results.Materials and method: This was an observational, descriptive, transversal survey, in children between the ages of 3 and 12, that participate in the “Programa de Salud Bucal de la Facultad de Odontología de la Universidad Católica del Uruguay”/ Oral Health Program of the Dentistry School of Uruguayan Catholic University. Lesions in the whole oral cavity were taken into account, describing and registering each one of the findings. The 7 lesions more frequent in the bibliography consulted were selected. A descriptive statisticalanalysis was made using the variables age, gender and dentition stages.Results: 191 children were examined; lesions were found in 103 children. Morsicatio buccarum, meaning the bitening of the cheek mucosa (self inflicted trauma), was the most common lesion. The second most frequent lesion was Geographic tongue. Conclusions: Girls had higher probability of presenting a lesion than boys. The age range between 6-9 had more risk of developing a lesion than the group ranging in age from 9-12. The children with mixed dentition had more risk of having Morsicatio buccarumthan the children with permanent dentition; and the children ranging in age from 6-9 had more probabilities of presenting Morsicatio buccarum than the children ranging 9-12. We could not find any other survey epidemiologically comparable that described the samelesions than ours. This leads to the conclussion that it is necessary to perform further studies with the same methodology and a wider range of diagnosis criteria.

Assessment of serum interleukin-8 as a sensitive serological marker in monitoring the therapeutic effect of levamisole in recurrent aphthous ulcers: A randomized control study.

Aim: The study was designed to evaluate the serum interleukin‑8 (IL‑8) levels in patients with recurrent aphthous ulcer (RAU) and monitor the immunomodulation and altered IL‑8 levels by levamisole before therapy and after levamisole therapy. Materials and Methods: This study was carried as a randomized case‑control study involving a study group of 30 patients diagnosed as RAUs and given levamisole (vermisole 150 mg, od for 1st 3 days of 3 weeks in a month and for 3 months with a gap of 1 week) and these patients were recalled after 3 months and were subjected for estimation of serum IL‑8 levels. Control group had 20 age and sex matched individuals with no systemic illness and were not given any levamisole. Good compliance was reported at the end of the study. Results: Mild gastric irritation was reported and when severe it was managed by H1 blocker. Patients were reviewed after 3 months. The follow‑up data at each visit with respect to each other and to base‑line values was calibrated using a Students t‑test. Highly significant comparisons were obtained in the serum IL‑8 between study and control groups before the onset of levamisole (t = 6.53, P ≤ 0.001). IL‑8 levels reduced by 72% after levamisole was instituted in RAU patients and comparison was highly significant for before and after levamisole onset (t = 5.54, P ≤ 0.001). Conclusion: This study points to the effectiveness of levamisole as an effective adjunct therapy in the routine management of RAU.

Dermatologic manifestations in inflammatory bowel disease in Tunisia

Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease [IBD]. To assess the epidemio-clinical profile of skin manifestations in IBD. A prospective and descriptive study was conducted. We have examined skin, mucosa, hair and nails, of all patients with an IBD during one year. One hundred-ninety-five patients were included. Crohn's disease [CD] was noted in 154 cases [79.8%], ulcerous rectocolitis [UC] in 39 cases [21.2%] and inclassable IBD in 2 cases. Cutaneous manifestations were found in 91% of Crohn's patients and in 92% of UC patients. Granulomatous perianal skin lesions were the main cutaneous manifestations of CD [53%]. The most common affected sites were ano-perineal fistulae, perianal and perineal fissures and oedematous and infiltrated perianal and genital plaques. Reactive lesions [Erythema nodosum, Pyoderma gangrenosum, Aphthous stomatitis] were noted in 14 cases. Skin manifestations due to malabsorption were also frequently observed [101 cases: 51.7%].Other dermatoses implicating various mechanisms such as psoriasis, alopecia areata, vitiligo, rosacea, lichen planus, were also noted. Adverse skin manifestations due to treatment [folliculitis, acne, macula-papular rash and DRESS syndrome] were present in 16 cases. Our series is characterized by a high frequency of cutaneous manifestations associated to IBD. A better recognition of these skin manifestations by the physician may improve their management

Comportamiento epidemiológico de la estomatitis aftosa recurrente en pacientes del Instituto Superior de Medicina Militar "Dr. Luis Díaz Soto", 2007 / Epidemiologic behavior of the recurrent aphthous stomatitis present in patients from Dr Luis Díaz Soto Higher Institute of Military Medicine, 2007

La estomatitis aftosa recurrente es una forma de ulceración que afecta la mucosa bucal, de presentación frecuente, que se caracteriza por la aparición de una o varias úlceras dolorosas, variable en forma, tamaño y número; las lesiones se repiten periódicamente. Cura en pocos días, semanas o meses, en dependencia de los factores de riesgo que la desencadenaron; para su tratamiento se han ensayado una gran cantidad de terapias, pero sin resolver el problema subyacente. Con el objetivo de evaluar el comportamiento epidemiológico de la estomatitis aftosa recurrente en pacientes atendidos en el Instituto Superior de Medicina Militar Dr Luis Díaz Soto en el período de junio de 2006 hasta febrero de 2007, se realizó un estudio descriptivo de corte transversal a 97 pacientes, de uno y otro sexo con diagnóstico de estomatitis aftosa recurrente. Se tuvieron en cuenta los grupos de edades a partir de 15 hasta 60 años y más. Se evaluaron las variables: sexo, edad, forma clínica de la lesión, posibles factores de riesgo y tratamiento indicado. Se confeccionó una base de datos informatizado; para comprobar la relación entre las variables se utilizó la prueba chi cuadrado y se aplicó el valor porcentual. Desde el inicio del estudio se tuvieron en cuenta las consideraciones éticas que deben regir toda investigación. La mayoría de los individuos encuestados presentaron la forma menor de la enfermedad; solo el 6,2 y el 4,2 por ciento padecieron la forma mayor y herpetiforme, respectivamente; la mayor afectación ocurrió en los individuos más jóvenes y en el sexo femenino; la terapia combinada fue la que más se aplicó en los pacientes, seguida de las diferentes técnicas de tratamientos alternativos; se usó únicamente el tratamiento convencional en muy pocos casos.

Recurrent aphthous stomatitis is a way of ulceration affecting buccal mucosa, has a frequent presentation characterizing appearance of one or some painful ulcers, with a variable size, number and way, lesions are periodically repeated. It is recovery in days, weeks or months, depending of risk factors triggering it. For treatment of this condition we assayed many therapies but without solution of underlying problem. The aim of present paper is to assess the epidemiologic behavior of recurrent stomatitis in patients seen in Dr. Luís Díaz Soto Higher Institute of Military Medicine from June 2006 to February 2007. We made a cross-sectional and descriptive study in 97 patients of both sexes diagnosed with this condition. We took into account age groups aged from 15 up to 60 or more. We assessed the following variables: sex, age, clinical presentation of lesion, possible risk factors and treatment prescribed. An information database was created; to verify relation among variables we used Chi2 test and percentage value was applied. From the beginning of study we took into account the ethical considerations that must to determine a research. Most of surveyed individuals had the lower way of disease, only the 6,2 and the 4,2 percent suffered from the great way and the herpertiform type, respectively; the greatest affection was present in younger individuals and in female sex; combined therapy was the more used in patients, followed by different techniques of alternative treatments; we used only the conventional treatment in very few cases.

Epidemiological and oral manifestations of HIV-positive patients in a specialized service in Brazil

The purpose of this study was to evaluate the prevalence of oral lesions in HIV-positive patients attending the Specialized Service for Infectious-contagious Diseases and Parasitoses of the Health Secretariat of the State of Pará (URE-DIPE/SESPA), in the city of Belém, PA, Brazil. A total of 79 HIV-positive patients (53 males and 26 females) were examined. Clinical and epidemiological evaluations were done by correlating the lesions with gender, race, chronological age, risk behavior and prevailing immune status (CD4+ cells count). Lesion location and the presence of associated factors, such as alcohol use, smoking and denture wearing, were quantified individually for each type of lesion using a diagnostic pattern based on the clinical aspects. Approximately 47% of the patients (n=37) presented some type of oral lesion. Candidiasis (28%) and periodontal disease (28%) were the most common, followed by cervical-facial lymphadenopathy (17.5%). Other lesions observed were hairy leukoplakia, melanin hyperpigmentation, ulcerative stomatitis (aphthous), herpes simplex, frictional keratosis and pyogenic granuloma. This analysis presented some relevance as to the statistical data. Concerning CD4+ cells, most lesions manifested with the reduction of the CD count. There were a larger number of HIV-positive female heterosexual patients. Alcohol and/or smoking were strongly associated with the occurrence of hairy leukoplakia in these patients. Candidiasis and periodontal disease were the most common oro-regional clinical manifestations in the patients.

Aspectos epidemiológicos da úlcera aftosa recorrente / Recurrent aphthous ulcers: epidemiologic aspects

Este estudo objetiva descrever os aspectos epidemiológicos da úlcera aftosa recorrente, de modo a contribuir com futuras investigações sobre a etiopatogenia dessa enfermidade que, ainda hoje, é desconhecida. A metodologia aplicada é classificada como tipicamente de campo, tendo em vista que o alicerce para a obtenção dos resultados partiu das análises de um questionário, com o qual 250 pessoas foram entrevistadas. Logo, com a apresentação deste estudo, esperamos colaborar com as pesquisas sobre a úlcera aftosa recorrente e despertar o interesse da classe odontológica sobre a importância do conhecimento das patologias bucais

Estudio clínico epidemiológico en aftas recidivantes bucales / A clinical and epidemiological study of recurrent oral aphthae

Se realizó un estudio epidemiológico en 119 pacientes que concurrieron al Servicio de Estomatología del CEMIC, con historia y diagnóstico de aftas recidivantes. Se evaluó el aspecto clínico, tamaño, localización, inicio, tiempo de evolución, historia familiar, factores generales (alt. hemáticas, hormonales, gastrointestinales), factores locales (sepsis y trauma). Si bien el factor local se hallaba presente en un 85 por ciento de los casos, los factores de orden general se presentaban concomitantemente con los mismos. La detección temprana de alteraciones orgánicas a través de esta patología resulta beneficiosa no sólo por el control de la misma, sino también por e diagnóstico precoz de las afecciones generales en ocasiones desconocidas por el paciente

Identificação do helicobacter pylori na estomatite aftosa recorrente através da imunocitoquímica / Identification of Helicobacter pylori in recurrent aphthous stomatitis by immunocytochemistry

A estomatite aftosa recorrente é uma afecção bucal comumente encontrada na população e vem sendo estudada por muitos pesquisadores para determinar a sua etiologia. Com a intenção de pesquisar a accociação do Helicobacter pylori com a EAR foram estudadas amostras coletadas por raspado de três sítios diferentes (mucosa labial inferior, fundo de vestíbulo inferior, úlcera) de 21 pacientes portadores de EAR que foram submetidos à técnica de imunocitoquímica, coloração pelos métodos Papanicolaou e Giemsa e comparados com amostras do grupo controle ... Comparando os resultados encontrados nas amostras provenientes da afta e as amostras do grupo controle, houve uma diferença significativa (p,0,001). Os resultados demonstram haver associação entre a EAR e a infecção pelo Helicobacter pylori.

La estomatitis aftosa recurrente en el diagnóstico de la enfermedad de Behcet / Recurrent apthous stomatitis in the diagnosis of Behcet's disease

La estomatitis aftosa recurrente (EAR) es también conocida como úlceras orales recurrentes, úlceras aftosas recurrentes o aftosis simple o compleja. La EAR es la afección inflamatoria de la mucosa oral más frecuente en pacientes de Norteamérica. Se ha investigado a la EAR desde el punto de vista epidemiológico, inmunológico, clínico y terapéutico. La evaluación clínica del paciente requiere un diagnóstico correcto de EAR y una clasificación de la enfermedad basada en su morfología (MiAU; MjAU; HU) y severidad (simple versus compleja). Para diagnosticar y tratar a un paciente con lesiones de EAR el clínico debe excluir otras causas de úlceras orales agudas. Deben considerarse las aftosis complejas y las variantes de aftosis complejas asociadas a enfermedades sistémicas. Las ulceraciones orales afta-símil de los pacientes con enfermedad por VIH constituyen un difícil diagnóstico diferencial. La asociación de lesiones de EAR con alteraciones hematológicas y trastornos gastrointestinales nos da la oportunidad de identificar "causas corregibles" que, con tratamiento apropiado, pueden causar la remisión o mejoría sustancial del cuadro. Finalmente, cuando se han considerado todos estos factores, la evolución de un paciente con diagnóstico de enfermedad de Behcet puede continuarse con sólidos fundamentos, dado que uno de sus criterios diagnósticos mayores se ha confirmado

Aftas bucales: prevalencia, historia y nivel socioeconómico en poblaciones seleccionadas de Argentina / Oral aphthae: prevalence, history and socio-economic status in selected populations from Argentina

Se estudió en una muestra de 10.742 personas, distribuidas en tres grupos representativos de poblaciones con distintas características socioeconómicas y culturales, la prevalencia e historia de aftas bucales por parte de un grupo especializado en patologia bucal clínical y experimentado en encuestas epidemiológicas. La prevalencia fue determinada por el examen bucal y la historia por el interrogatorio. Se registró un 0,7% de prevalencia para el total de la muestra, con diferencias estadísticamente significativas para los grupos de diferente nivel socioeconómico. Los valores de historia de aftas bucales en estudiantes universitários de odontología fueron elevados (41,8%) y comparables a los obtenidos por otros autores en poblaciones similares